|
KMID : 0360319940260050722
|
|
Journal of Korean Cancer Research Association
1994 Volume.26 No. 5 p.722 ~ p.727
|
|
|
A Study of Estrogen Receptors in Gastric Cancer
|
|
|
|
|
Abstract
|
|
|
Recently the presence of estrogen receptor(ER) has been demonstrated in some cases of cancer of the digestive tract such as stomach, large intestine, pancreas and the liver which are non-target organs of sex hormones.
The authors studied ER in tumors from 95 gastric adenocarcinomas using immunohistochemical staining with monoclonal antibody. DNA ploidy using flow cytometry was also assessed in 75 cases of gastric carcinomas.
ER positivity was 40 of 95(42.1%) gastric carcinomas. The tendency of receptor positivity increased with progression of tumor and lower differentiation. There was no positive relationship between ER positivity and sex, age, gross type, DNA ploidy
and
the level of carcinoembryonic antigen.
The results of this study show that hormonal factors are involved in gastric carcinomas and that the cancers have endocrinic characteristics. The studies clarifying the role of hormones to cancer cells will be valuable in the design of hormonal
therapy.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|